Structure of PDB 8gjh Chain A

Receptor sequence
>8gjhA (length=639) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium) [Search protein sequence]
MKAVIFAYHDMGCQGVQAVLDAGYEIAAIFTHADGSVSRQAAELGIPVYA
PDNVNHPIWVDRIAELAPDIIFSFYYRNLLSEEILHLAPAGAFNLHGSLL
PAYRGRAPLNWVLVNGESETGVTLHRMVKRADAGEIVASQRVAIAQDDVA
LTLHHKLCQAARQLLNSILPTMKCGDIPSVPQRESDSTYYGRRRPEDGLI
DWHKPVSTVHNLVRAVAAPWPGAFSYNGSQKFTIWSSRMCPDAQGALPGS
VISVSPLRVACADGALEIITGQAGDDITVQGSQLAQTLGLVAGARLRRIR
VLILGVNGFIGNHLTERLLNEENYEVYGMDIGSNAISRFLLHPRFHFVEG
DISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRII
RYCVKYRKRVVFPSTSEVYGMCTDASFDEDKSNLIVGPVNKPRWIYSVSK
QLLDRVIWAYGEKEGLRFTLFRPFNWMGPRLDSLNAARIGSSRAITQLIL
NLVEGTPIKLIDGGQQKRCFTDIRDGIEALFRIIVNDGDRCDGKIINIGN
PDNEASIQELATLLLDSFDKHPLRCHFPPFAGFQVVESRSYYGKGYQDVA
HRKPSIDNARRCLGWEPSIAMRDTVEETLDFFLRSVDIA
3D structure
PDB8gjh Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.305: UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating).
2.1.2.13: UDP-4-amino-4-deoxy-L-arabinose formyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UGA A A393 P395 Y398 S433 R460 N492 R510 A511 K526 I528 R535 I574 Y609 R619 A376 P378 Y381 S416 R443 N475 R493 A494 K509 I511 R518 I557 Y592 R602
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0016831 carboxy-lyase activity
GO:0099618 UDP-glucuronic acid dehydrogenase activity
GO:0099619 UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009245 lipid A biosynthetic process
GO:0046493 lipid A metabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:8gjh, PDBe:8gjh, PDBj:8gjh
PDBsum8gjh
PubMed37410993
UniProtO52325|ARNA_SALTY Bifunctional polymyxin resistance protein ArnA (Gene Name=arnA)

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