Structure of PDB 8gip Chain A

Receptor sequence

>8gipA (length=356) Species: 10090 (Mus musculus) [Search protein sequence]

DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRINPLSH
FLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRN
PEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPK
NAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKL
MKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFD
KLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNG
FPIFDK

3D structure

PDB

8gip The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 R161 H203 E386 K395	R11 L12 R14 H56 E236 K245
BS02	dna	A	R161 S165 A168 N196 Y200 Y201 K372	R14 S18 A21 N49 Y53 Y54 K222
BS03	dna	A	T334 K335 T338	T184 K185 T188
BS04	dna	A	K315 G316 R342	K165 G166 R192
BS05	ATP	A	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421	G51 S52 E64 D66 R214 S218 E221 K252 S270 Y271
BS06	MG	A	E211 D213	E64 D66
BS07	ZN	A	H378 C385 C392	H228 C235 C242
BS08	MN	A	E211 D213 D307	E64 D66 D157

External links

PDB	RCSB:8gip, PDBe:8gip, PDBj:8gip
PDBsum	8gip
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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