Structure of PDB 8ghr Chain A

Receptor sequence
>8ghrA (length=735) Species: 9606 (Homo sapiens) [Search protein sequence]
EKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVIS
KLKKCGTYTKNMRPVYPTKAFPNHYSIVTGLYPESHGIIDNKMYDPKMNA
SFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDI
YKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVS
SEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIY
LNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQH
FKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHG
SDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNG
THGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIE
DFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQD
ILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVS
YGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAE
ERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLT
SCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHR
ARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTF
3D structure
PDB8ghr Discovery of VH domains that allosterically inhibit ENPP1.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D376 H380 H535 D190 H194 H349
BS02 ZN A D218 D423 H424 D32 D237 H238
BS03 AMP A A256 Y340 Y371 H535 A70 Y154 Y185 H349
BS04 CA A D800 D804 R806 D808 D614 D618 R620 D622
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8ghr, PDBe:8ghr, PDBj:8ghr
PDBsum8ghr
PubMed37400538
UniProtP0DOX5|IGG1_HUMAN Immunoglobulin gamma-1 heavy chain;
P22413|ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Gene Name=ENPP1)

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