Structure of PDB 8ghh Chain A

Receptor sequence
>8ghhA (length=276) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
TIPAFFKGNAPYIFAHRGGMALRPEQTQLAFDYAKQLGVDGFETDVRLTK
DQQLIVFHDATVDRTTNGSGKVSAHTLAELKKLDAAYHFKDINGLTPYRG
HAHTAILTFDELLKQYPDMYINVDLKDAPESYEGSIAPQIMFDTIAENQA
FDRVLVTSFYKEQIVRFNKIAQGSVAIGASQQEVTEAFLKYHLLGGRYYQ
PLAQTFQMPTHFKGIDLTSSRFIKWLNDMNIIPGYYGVNSINLMNDLYQK
GAHTIVTDRPDLAQQFKQTIPNKLEH
3D structure
PDB8ghh Lysophosphatidylglycerol (LPG) phospholipase D maintains membrane homeostasis in Staphylococcus aureus by converting LPG to lysophosphatidic acid.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.46: glycerophosphodiester phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2HP A H51 R52 E78 D80 K161 H16 R17 E43 D45 K126
BS02 GOL A E60 R99 E25 R64
BS03 GOL A H123 R134 H88 R99
BS04 GOL A T192 A214 Q216 Q242 T157 A179 Q181 Q207
BS05 GOL A H246 K248 G249 H211 K213 G214
BS06 GOL A M55 F124 K125 M20 F89 K90
BS07 GOL A R82 H93 D94 A95 R47 H58 D59 A60
BS08 GOL A R82 K161 A163 Y195 R47 K126 A128 Y160
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ghh, PDBe:8ghh, PDBj:8ghh
PDBsum8ghh
PubMed37236358
UniProtA0A0D6HT57

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