Structure of PDB 8ghf Chain A

Receptor sequence
>8ghfA (length=910) Species: 9606 (Homo sapiens) [Search protein sequence]
QRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCAAEVGWMTSVKDWAG
VMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQI
DMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRS
WLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGF
IHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRL
FMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHIT
LESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQ
GSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHP
KIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQG
LSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPT
VCELCFVKLKLLMIAIEYSRILINPGNHLKIQEGTLGFFIASDAKEVKRA
FFYCKVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDV
SSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNI
KSMQFDTTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTA
FAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYS
TPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDAAAAAAAA
AAAAAAAAAA
3D structure
PDB8ghf Membrane protein isolation and structure determination in cell-derived membrane vesicles.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D367 R514 S533 E535 S600 D315 R462 S481 E483 S542
BS02 CA A Q889 D892 D895 D897 Q725 D728 D731 D733
BS03 CLR A F188 L206 F136 L154
BS04 CLR A W22 W23 W4 W5
BS05 CLR A S28 V31 Y198 S10 V13 Y146
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ghf, PDBe:8ghf, PDBj:8ghf
PDBsum8ghf
PubMed37098056
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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