Structure of PDB 8gh7 Chain A

Receptor sequence
>8gh7A (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
STNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFH
CGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT
3D structure
PDB8gh7 Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G306 L307 T308 D309 W310 E314 Q319 W323 Y324 G54 L55 T56 D57 W58 E62 Q67 W71 Y72
BS02 peptide A L292 K299 G306 L307 L40 K47 G54 L55
BS03 ZN A C300 C303 H320 C327 C48 C51 H68 C75
External links
PDB RCSB:8gh7, PDBe:8gh7, PDBj:8gh7
PDBsum8gh7
PubMed37262387
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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