Structure of PDB 8ges Chain A

Receptor sequence
>8gesA (length=644) Species: 301301 (Roseburia hominis) [Search protein sequence]
MREVINFNTKWAFTKEATEVPKEMPEKWYWVTLPHSWNEIDGQDGGNDYY
RGTCYYAKQLKKSELPEADCYYLELRGANASADVYVNGKAVAHHDGGYST
WRVDITKELTEEENLIVIAVENGVNDRVYPQNADFTFYGGLYRDVNIIAV
NKSHFDLDYYGGPGIKVTPEIKGADASVEVEVFLTNAAADQKLVYTVKDA
EGKEVAKTETAAGETKAVLSIPAVHLWNGKKDPYLYTAEVALVSGEEAVD
AVSTRFGCRTFEIDPERGFILNGEEYPLRGVSRHQDRWGIGNALLPEHHR
EDIDLICELGATTIRLAHYQHDQYFYDLCDERGLVIWAEIPYISSHMPNG
RENTISQMKELVVQNYNHPSIVVWGLSNEITMAGSSDEDLLENHRILNDM
VHEMDHTRLTTIAVVSMCDIHDPYIQIPDVISYNHYFGWYGGDVSMNGPW
MDNFHKEFPNIPLGMSEYGCEALNWHTSDPKQGDYTEEYQAYYHEEMIKQ
LFTRKYIWATHVWNMFDFGADARNEGGENGQNHKGLVTFDRKYKKDSFYA
YKAWLSDEPFVHLCGKRYVDRVEDTTKVTVYSNLPEVELFVNGKSAGKLQ
AEDHFFHFEVPNVGESTLVAVAGEYKDESHIRKVDTFNEEYSLK
3D structure
PDB8ges Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A D155 Y158 F183 K359 V363 Y366 M404 D156 Y159 F183 K359 V363 Y366 M404
BS02 I9G A D133 H318 N378 E379 M382 Y436 Y440 E467 W513 R523 N532 K534 D134 H318 N378 E379 M382 Y436 Y440 E467 W513 R523 N532 K534
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ges, PDBe:8ges, PDBj:8ges
PDBsum8ges
PubMed38754417
UniProtA0A395V8I7

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