Structure of PDB 8geo Chain A

Receptor sequence
>8geoA (length=581) Species: 39485 (Lachnospira eligens) [Search protein sequence]
AMLYPVLTQSRLLSDLSGVWNFKLDNGKGFEEKWYEKPLKDADTMPVPAS
YNDLKEGTDFRDHYGWVFYQRNISVPEYVKSQRIVLRCAAVTHYAMIYLN
GKLICEHKGGFLPFEVELNDDLQDGDNLLTIAVNNVIDYTTLPVGGKAPQ
NNPNFDFFNYCGITRPVKIYTTPETYINDITVTADIDFTKEEPSAVLNYN
VEIKGKDITCKVELFDEEGTKLSETEGSEGTFEISNVRLWQPLNAYLYKI
KVTAGQDVYTLPYGVRSVRVDGTKFLINEKPFYFKGYGKHEDTFPNGRGI
NLPMNTKDISIMKWQHANSFRTSHYPYSEEMMRLCDEEGIVVIDETTAVG
VNLGERIGTFDKEHGVQTQEHHKDVIRDLISRDKNHACVVMWSIANEPDS
AAEGAYDYFKPLYDLARELDPQKRPCTLVSVQGTTADTDCSSQLSDVICL
NRYYGWYFGGPDLEVSETGLRKELSDWGKLGKPVMFTEYGADTVSGLHDT
TSVMYTEEYQVEYYEMNNKVFDEFDFVVGEQAWNFADFATSQSLLRVQGN
KKGLFTRDRKPKMVAHYFRNRWSAIPEFGYK
3D structure
PDB8geo Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.31: beta-glucuronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZBL A D172 H343 N424 E425 V459 Y481 Y485 E516 W561 K580 D156 H324 N396 E397 V431 Y453 Y457 E488 W533 K552
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0004566 beta-glucuronidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8geo, PDBe:8geo, PDBj:8geo
PDBsum8geo
PubMed38754417
UniProtA0A174ZZA3

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