Structure of PDB 8gce Chain A

Receptor sequence
>8gceA (length=912) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQ
KLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMA
FLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVL
DCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELA
VHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIG
IAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVEL
RGNSFPASLVVAASWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSD
LLYILDIQPQGGLQCFPQPPVNPLKVDDPVLVSCDSAPCTVVQCDLQEMA
RGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPR
GEAQVWTQLLRA
3D structure
PDB8gce Full-length AlphaIIbBeta3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture
ChainA
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E243 L248 E243 L248
BS02 CA A D297 N299 D301 R303 D305 D297 N299 D301 R303 D305
BS03 CA A D367 D369 D373 D367 D369 D373
BS04 CA A D426 D428 N430 D434 D426 D428 N430 D434
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8gce, PDBe:8gce, PDBj:8gce
PDBsum8gce
PubMed38579706
UniProtP08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)

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