Structure of PDB 8gbf Chain A

Receptor sequence

>8gbfA (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

8gbf Crystal structure of human DNA polymerase eta incorporating syn-ITP across dT

Chain

Resolution

2.11 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 R61 S62 W64 K86 K293 R313 P316 K317 T318 I319 G320 S322 K323 N324 P326	Q37 Y38 W41 R60 S61 W63 K85 K287 R307 P310 K311 T312 I313 G314 S316 K317 N318 P320
BS02	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 R377 R382	S112 E115 K218 S251 G253 G254 K255 L256 R371 R376
BS03	CZU	A	D13 C16 F18 R55 R61 D115 K231	D12 C15 F17 R54 R60 D114 K225
BS04	CA	A	D13 M14 D115	D12 M13 D114

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8gbf, PDBe:8gbf, PDBj:8gbf
PDBsum	8gbf
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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