Structure of PDB 8gb4 Chain A

Receptor sequence

>8gb4A (length=292) Species: 9606 (Homo sapiens)

NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM

3D structure

• PDB: 8gb4 EGFR(T790M/V948R) kinase in complex with benzimidazole allosteric inhibitor
• Chain: A
• Resolution: 2.59 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	N842 D855	N143 D156
BS02	ANP	A	G719 S720 G721 V726 A743 M790 Q791 M793 D837 R841 N842 D855	G20 S21 G22 V27 A44 M91 Q92 M94 D138 R142 N143 D156
BS03	YW5	A	A743 I744 K745 A755 I759 M766 C775 R776 L777 L788 I789 M790 D855 F856 L858	A44 I45 K46 A56 I60 M67 C76 R77 L78 L89 I90 M91 D156 F157 L159

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:8gb4, PDBe:8gb4, PDBj:8gb4
• PDBsum: 8gb4
• UniProt: P00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)