Structure of PDB 8g9f Chain A

Receptor sequence
>8g9fA (length=1063) Species: 8355 (Xenopus laevis) [Search protein sequence]
QVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCVSVKNIERTVY
LLPRENRVQLSTGKDTGAPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD
YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFL
LSRKIKGPSWLEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKDLAPPPVV
VLSLSMKTVQNAKTHQNEIVAIAALVHHTFPLDKAPPQPPFQTHFCVLSK
LNDCIFPYDYNEAVKQKNANIEIALTERTLLGFFLAKIHKIDPDVIVGHD
IYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRSGFAERNAACGR
IICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYNDSVHL
LYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERN
EYLLLHAFTENNFIVPDKPVGLVLEPKVGFYDKFILLLDFNSLYPSIIQE
YNICFTTVHREIPELPHSDLEMGILPREIRKLVERRRHVKQLMKQPDLNP
DLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTHQGREILLH
TKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSEINKSYKLL
EIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLDIVRRDWCE
LAKQAGNYVISQILSDQPRDSIVENIQKKLTEIGENVTNGTVPITQYEIN
KALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTISYVICQDGSNL
SASQRAYAQEQLQKQENLSIDTQYYLSQQVHPVVARICEPIDGIDSALIA
MWLGLDPSQFRDEENDALLGGPSQLTDEEKYRDCERFKFFCPKCGTENIY
DNVFDGSGLQIEPGLKRCSKPECDASPLDYVIQVHNKLLLDIRRYIKKYY
SGWLVCEEKTCQNRTRRLPLSFSRNGPICQACSKATLRSEYPEKALYTQL
CFYRFIFDWDYALEKVVSEQERGHLKKKLFQESENQYKKLKSTVDQVLSR
SGYSEVNLSKLFQ
3D structure
PDB8g9f A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1280 C1283 C1307 C1312 C891 C894 C918 C923
BS02 ZN A C1345 C1350 C1368 C1371 C956 C961 C979 C982
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:1902975 mitotic DNA replication initiation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8g9f, PDBe:8g9f, PDBj:8g9f
PDBsum8g9f
PubMed38491139
UniProtQ9DE46|DPOLA_XENLA DNA polymerase alpha catalytic subunit (Gene Name=pola1)

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