Structure of PDB 8g8n Chain A

Receptor sequence

>8g8nA (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]

QVQLVQSGAEVKKPGSSVKVSCKASGYTFTNYFMNWVRQAPGQGLEWMGR
VDPEQGRADYAEKFKKRVTITADKSTSTAYMELSSLRSEDTAVYYCARRA
MDNYGFAYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH
KPSNTKVDKKVEP

3D structure

PDB

8g8n XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.

Chain

Resolution

3.0 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	N31 R50 D52 E54 R99 Y104	N31 R50 D52 E54 R99 Y104

External links

PDB	RCSB:8g8n, PDBe:8g8n, PDBj:8g8n
PDBsum	8g8n
PubMed	38164757

[Back to BioLiP]