Structure of PDB 8g6p Chain A

Receptor sequence
>8g6pA (length=508) Species: 1797 (Mycolicibacterium thermoresistibile) [Search protein sequence]
HMMNLRPSDPVGASLRHLAEQVHAVPIGSVEVPDLHISGITLRSQDARRG
DLFAALAGASAHGADHAADAVARGAVAVLTDSAGATRLDGTVPAPVLVHP
NPRTVLGELAATVYGRPADRLRVIGITGTSGKTTTAYLVEAGLRAADRVP
GLIGTVGVRIDGMDEPSALTTPEAPDLQALLAVMADRGVDTVVMEVSSHA
LSLHRVDGVRFAVGGFTNLSRDHLDFHPTMADYFAAKARLFDPQAPTCAE
RSVICIDDEAGRAMLAGAHRPVSVSATGQRADWVAEDVRFAGPTAQDFTA
VDPAGVRHRLRVGLPGRFNIANCLLAVALLDAVGVSPAQAAPGLRTATVP
GRLEPVDRGQDFLALVDYAHKPGALSAVLDSLRASATGRLAVVFGAGGNR
DPGKREEMGRVAAERADLVVVTDDNPRDEDPAAIRAAIVAGAKSVAGQAQ
IVEIADRREAIDHAVRWAGAGDVVLIAGKGHESGQTRGGQTRPFDDRAEL
AAALVART
3D structure
PDB8g6p The crystal structure of Mycobacterium thermoresistibile MurE ligase reveals the binding mode of the substrate m-diaminopimelate.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.13: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T127 S128 G129 K130 T131 T132 N216 F316 N320 R350 D365 A367 A375 V376 T129 S130 G131 K132 T133 T134 N218 F318 N322 R352 D367 A369 A377 V378
BS02 API A H368 R398 D422 N423 R425 G476 E480 H370 R400 D424 N425 R427 G478 E482
BS03 MG A T153 E193 T155 E195
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0008765 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g6p, PDBe:8g6p, PDBj:8g6p
PDBsum8g6p
PubMed36944394
UniProtG7CMG5

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