Structure of PDB 8g5m Chain A

Receptor sequence
>8g5mA (length=932) Species: 9606 (Homo sapiens) [Search protein sequence]
LSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLP
PLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRY
GPEGEAVPVAIPEERALVFAVAVCLAEGTCPTLAVAISPSAWYSWCSQRL
VEERYSWTSQLSPADLIPLEVRDWQEQLVVGHNVSFDRAHIREQYLIQGS
RMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHARRGPAISSWDWLDISS
VNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWA
THEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTY
EELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQPMDQE
DLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCP
RLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLNDVDI
PGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEI
NKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQV
VTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQ
ELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISRE
HAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRW
YRWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSR
VNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDR
YRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMD
CKTPSNPTGMERRYGIPQGEALDIYQIIELTK
3D structure
PDB8g5m Structural basis for DNA proofreading.
ChainA
Resolution2.58 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A P765 K768 T861 A862 R869 P521 K524 T617 A618 R625
BS02 dna A F307 S310 R337 R338 L558 M596 Y614 F961 F220 S223 R235 R236 L430 M468 Y486 F717
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g5m, PDBe:8g5m, PDBj:8g5m
PDBsum8g5m
PubMed38151585
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

[Back to BioLiP]