Structure of PDB 8g5l Chain A

Receptor sequence
>8g5lA (length=913) Species: 9606 (Homo sapiens) [Search protein sequence]
MLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRL
PPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTR
YGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQR
LVEERYSWTSQLSPADLIPLEVQEQLVVGHNVSFDRAHIREQYLIQGSRM
RFLDTMSMHMAISGLSSFQRSLWIAAKPAISSWDWLDISSVNSLAEVHRL
YVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLP
LFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKS
LMDLANDACQLLSGERYKEDPWLWDLEWDLQEFSEEEEFQQDVMARACLQ
KLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTP
KLMALTWDGFPLHYSERHGWGYLVPGPYNDVDIPGCWFFKLPHKDGNSCN
VGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQ
MVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLT
ASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMH
GCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPF
AERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLKGGTESEMFNKLES
IATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLML
VAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCM
FAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIP
QGEALDIYQIIEL
3D structure
PDB8g5l Structural basis for DNA proofreading.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D198 G268 H269 N270 F273 D274 R309 S355 K371 D399 R562 P563 Q564 K768 N803 D121 G179 H180 N181 F184 D185 R220 S243 K259 D287 R412 P413 Q414 K507 N542
BS02 dna A S306 F307 S310 S593 Q595 M596 R597 S217 F218 S221 S443 Q445 M446 R447
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g5l, PDBe:8g5l, PDBj:8g5l
PDBsum8g5l
PubMed38151585
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

[Back to BioLiP]