Structure of PDB 8g5k Chain A

Receptor sequence
>8g5kA (length=905) Species: 9606 (Homo sapiens) [Search protein sequence]
MLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRL
PPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTR
YGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQR
LVEERYSWTSQLSPADLIPLEVQEQLVVGHNVSFDRAHIREQYLIQGSRM
RFLDTMSMHMAISGLSSFQRSLWIAAKPAISSWDWLDISSVNSLAEVHRL
YVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLP
LFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKS
LMDLANDACQLLSGERYKEDPWLWDLEWDLQEFSEEEEFQQDVMARACLQ
KLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTP
KLMALTWDGFPLHYSERHGWGYLVPGYNDVDIPGCWFFKLPHKDGNSCNV
GSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQM
VVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTA
SNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHG
CTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFA
ERLLMQFNHRLTQQEAAEKAQQMYAATKGLRESEMFNKLESIATSDIPRT
PVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEE
FAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLND
LPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQ
IIELT
3D structure
PDB8g5k Structural basis for DNA proofreading.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R309 A767 K768 N803 R807 R220 A505 K506 N541 R545
BS02 dna A F307 S310 L559 Q595 M596 R597 F218 S221 L409 Q445 M446 R447
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g5k, PDBe:8g5k, PDBj:8g5k
PDBsum8g5k
PubMed38151585
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

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