Structure of PDB 8g5h Chain A

Receptor sequence
>8g5hA (length=340) Species: 10090 (Mus musculus) [Search protein sequence]
TIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTI
DVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNM
TTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAY
TKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVV
MTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT
VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK
RSWAWEGKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYV
3D structure
PDB8g5h Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainA
Resolution2.89 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU A F89 T154 F53 T118
BS02 PIO A R273 E327 F334 R337 S423 S425 V427 R237 E291 F298 R301 S312 S314 V316
BS03 Y4B A I263 W270 P436 I227 W234 P325
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8g5h, PDBe:8g5h, PDBj:8g5h
PDBsum8g5h
PubMed37730991
UniProtP26049|GBRA3_MOUSE Gamma-aminobutyric acid receptor subunit alpha-3 (Gene Name=Gabra3)

[Back to BioLiP]