Structure of PDB 8g5g Chain A

Receptor sequence
>8g5gA (length=344) Species: 10090 (Mus musculus) [Search protein sequence]
DNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDME
YTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVA
HNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS
YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGE
YVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG
VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY
FTKRGYAWDGKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLN
3D structure
PDB8g5g Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainA
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIO A R248 F309 K311 R312 S387 S389 K390 I391 L394 R240 F301 K303 R304 S315 S317 K318 I319 L322
BS02 Y4B A Q241 V242 W245 Q233 V234 W237
BS03 ABU A F64 R66 L117 F56 R58 L109
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g5g, PDBe:8g5g, PDBj:8g5g
PDBsum8g5g
PubMed37730991
UniProtP62812|GBRA1_MOUSE Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=Gabra1)

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