Structure of PDB 8g5d Chain A

Receptor sequence
>8g5dA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
VPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIG
GVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDL
VSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLI
MGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVAGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFI
GHYLDQKRLKQGLYRHPWDDISYVLPEHM
3D structure
PDB8g5d Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A A938 M971 G972 I973 G974 R976 N1024 A1026 A118 M151 G152 I153 G154 R156 N204 A206
BS02 OAA A H900 F935 H80 F115
BS03 ACO A R1085 H1086 P1087 W1088 R265 H266 P267 W268
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003878 ATP citrate synthase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0006101 citrate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0015936 coenzyme A metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g5d, PDBe:8g5d, PDBj:8g5d
PDBsum8g5d
PubMed37076498
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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