Structure of PDB 8g46 Chain A

Receptor sequence
>8g46A (length=782) Species: 9606 (Homo sapiens) [Search protein sequence]
SYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRP
VKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDII
TRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKE
LKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKE
FNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPP
IIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLR
VELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAME
TFTNLGPIVDMCVVDLGQGQLVTCSGAFKEGSLRIIRNGKLHIRTVPLYE
SPRKICYQEVSQCFGVLSSRIEVTTALRPSASTQALSSSVSSSEEVEVHN
LLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEE
AEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRL
YEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEG
NFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQ
HLQEVGLFHLGEFVNVFCHGSLVMQTPTQGSVLFGTVNGMIGLVTSLSES
WYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIES
FLDISRPKMQEVVANLATADDLIKVVEELTRI
3D structure
PDB8g46 Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H22 E27 L29 V44 T45 A46 E47 G48 V264 R270 L284 E303 L305 Y316 L317 D318 N319 V321 V338 Y346 M350 E351 H21 E26 L28 V43 T44 A45 E46 G47 V263 R269 L283 E302 L304 Y315 L316 D317 N318 V320 V337 Y345 M349 E350
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8g46, PDBe:8g46, PDBj:8g46
PDBsum8g46
PubMed36824856
UniProtQ16531|DDB1_HUMAN DNA damage-binding protein 1 (Gene Name=DDB1)

[Back to BioLiP]