Structure of PDB 8g3y Chain A

Receptor sequence
>8g3yA (length=515) Species: 1327989 (Serratia sp. FS14) [Search protein sequence]
GKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYEYDIKDVGVDNAGAKAGLTFLVDLIKNK
HMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKG
QPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAV
ALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAAS
GRQTVDEALKDAQTGSELYRQSLEIISRYLREQATGAADTAPMGASGATS
RKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSD
GVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWL
VKQRGWDGFVEFFHV
3D structure
PDB8g3y Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D-182 K-181 E-85 Y-41 W34 D15 K16 E112 Y156 W228
BS02 GLC A W-134 D-131 R-130 E-43 P-42 Y-41 W144 W63 D66 R67 E154 P155 Y156 W338
BS03 YKL A H224 A227 F228 M231 V249 M250 V253 F254 G262 R263 T266 L267 F270 H418 A421 F422 M425 V443 M444 V447 F448 G456 R457 T460 L461 F464
Gene Ontology
Molecular Function
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0008643 carbohydrate transport
GO:0042981 regulation of apoptotic process
GO:0055085 transmembrane transport

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Molecular Function
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Biological Process
External links
PDB RCSB:8g3y, PDBe:8g3y, PDBj:8g3y
PDBsum8g3y
PubMed37114951
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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