Structure of PDB 8g3w Chain A

Receptor sequence
>8g3wA (length=518) Species: 1327989 (Serratia sp. FS14) [Search protein sequence]
GKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDEALKDAQTGSELYRQSLEIISRYLREQATGAADTAPMGASG
ATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHV
FSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKR
DWLVKQRGWDGFVEFFHV
3D structure
PDB8g3w Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D-182 K-181 E-85 Y-41 W34 D15 K16 E112 Y156 W231
BS02 GLC A W-134 D-131 R-130 E-43 P-42 Y-41 W144 W63 D66 R67 E154 P155 Y156 W341
BS03 YKX A H224 M250 V253 G262 R263 T266 L267 F270 H421 M447 V450 G459 R460 T463 L464 F467
Gene Ontology
Molecular Function
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0008643 carbohydrate transport
GO:0042981 regulation of apoptotic process
GO:0055085 transmembrane transport

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Molecular Function
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Biological Process
External links
PDB RCSB:8g3w, PDBe:8g3w, PDBj:8g3w
PDBsum8g3w
PubMed37114951
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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