Structure of PDB 8g2p Chain A

Receptor sequence

>8g2pA (length=347) Species: 10090 (Mus musculus) [Search protein sequence]

DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFGNPLSHFL
EGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPE
EISVNIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKQG
ETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKK
EFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECL
RTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL

3D structure

PDB

8g2p Structure of Ternary Complex of cGAS with dsDNA and Bound ATP and GTP

Chain

Resolution

2.521 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 H203 E386 K395	R11 L12 K13 R14 H56 E226 K235
BS02	dna	A	R161 S165 A168 N196 Y200 Y201 K372	R14 S18 A21 N49 Y53 Y54 K212
BS03	dna	A	T334 K335 T338	T182 K183 T186
BS04	ATP	A	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421	G51 S52 E64 D66 R204 S208 E211 K242 S260 Y261
BS05	GTP	A	T197 S291 P292 N307 I309 R364 S366 S368	T50 S139 P140 N155 I157 R204 S206 S208
BS06	MG	A	E211 D213	E64 D66
BS07	ZN	A	H378 C385 C392	H218 C225 C232

External links

PDB	RCSB:8g2p, PDBe:8g2p, PDBj:8g2p
PDBsum	8g2p
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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