Structure of PDB 8g2g Chain A

Receptor sequence
>8g2gA (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
DGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGT
GILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEV
HLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTIS
LVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEP
CGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNR
VVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLT
VTLTLNNSTQTYGLQ
3D structure
PDB8g2g Crystal structure of PRMT3 with compound YD1113
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YVU A F221 Y224 M233 R239 T240 Y243 G263 C264 I268 L269 D285 Q286 K312 I313 E314 E329 M340 S343 F5 Y8 M17 R23 T24 Y27 G47 C48 I52 L53 D69 Q70 K96 I97 E98 E113 M124 S127
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8g2g, PDBe:8g2g, PDBj:8g2g
PDBsum8g2g
PubMed38045046
UniProtO60678|ANM3_HUMAN Protein arginine N-methyltransferase 3 (Gene Name=PRMT3)

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