Structure of PDB 8g18 Chain A

Receptor sequence
>8g18A (length=359) Species: 8355 (Xenopus laevis) [Search protein sequence]
DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAI
QMALSVCEDLISSQVYAILVSHPPALTPTPISYTAGFYRIPVIGLTTRMS
IYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAA
QKKLETLLEGGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDD
ATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNE
SAHISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMS
SKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDR
KIIWPGGET
3D structure
PDB8g18 Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YGW A Y109 S132 I133 L135 Y83 S106 I107 L109
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8g18, PDBe:8g18, PDBj:8g18
PDBsum8g18
PubMed36779874
UniProtA0A8J0TPH2

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