Structure of PDB 8fyy Chain A

Receptor sequence
>8fyyA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
SKLPKPVQDLIKMIFDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTH
ATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGI
LSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLG
EVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLG
TGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK
3D structure
PDB8fyy Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A F851 D993 F79 D221
BS02 FRU A P942 G944 K945 H946 P170 G172 K173 H174
BS03 YH0 A H862 G863 T887 G888 Y889 Y896 F897 A898 S904 Y907 H90 G91 T115 G116 Y117 Y124 F125 A126 S132 Y135
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8fyy, PDBe:8fyy, PDBj:8fyy
PDBsum8fyy
PubMed38372302
UniProtP09874|PARP1_HUMAN Poly [ADP-ribose] polymerase 1 (Gene Name=PARP1)

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