Structure of PDB 8fy1 Chain A

Receptor sequence
>8fy1A (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIH
SYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKE
RCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQE
3D structure
PDB8fy1 Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
ChainA
Resolution2.56 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YF8 A R69 W88 Y98 P99 L101 I109 H110 S111 Y112 H115 W117 R9 W28 Y38 P39 L41 I49 H50 S51 Y52 H55 W57
External links
PDB RCSB:8fy1, PDBe:8fy1, PDBj:8fy1
PDBsum8fy1
PubMed38548768
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

[Back to BioLiP]