Structure of PDB 8fxn Chain A

Receptor sequence
>8fxnA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPM
DLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAE
VFEQEIDPVMQSLG
3D structure
PDB8fxn Group 3 medulloblastoma transcriptional networks are sensitive to EP300/CBP bromodomain inhibition
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YN0 A L1109 P1110 F1111 Q1113 V1115 L1119 L1120 N1168 V1174 L26 P27 F28 Q30 V32 L36 L37 N85 V91
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8fxn, PDBe:8fxn, PDBj:8fxn
PDBsum8fxn
PubMed
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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