Structure of PDB 8fx4 Chain A

Receptor sequence
>8fx4A (length=623) Species: 10029 (Cricetulus griseus) [Search protein sequence]
EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGT
KAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS
AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIG
YPITLYLEKEDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLA
VKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCD
ELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFS
ELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMT
SLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPI
DEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLM
KEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTM
GYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSG
FSLEDPQTHSNRIYRMIKLGLGI
3D structure
PDB8fx4 Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A N46 M93 G109 T110 G130 F133 T179 N36 M83 G99 T100 G120 F123 T169
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0097718 disordered domain specific binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0034605 cellular response to heat
GO:0050821 protein stabilization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0042470 melanosome
GO:0048471 perinuclear region of cytoplasm
GO:0120293 dynein axonemal particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fx4, PDBe:8fx4, PDBj:8fx4
PDBsum8fx4
PubMed37535399
UniProtA0A8C2MUK8

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