Structure of PDB 8fx2 Chain A

Receptor sequence
>8fx2A (length=216) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
VHVVSRNAEGVIVVDGKAYPMAEELVATESVIQRSIKAVAKQIADFYRPL
SHRDTHGGGGVAPISDENPLIIISVLKGSYIFTADMVRYLGDYGLPHVVD
FLRVASYKMQLLAETQFKALRGKHVLILEDIVDSGKTLRYILDKVQREHQ
PATLKVCVLADKPGGRRVTMQPDFVCLTVPNKYVIGYGFEVNDRFRCFRH
IFTLRPGEARRYPAHL
3D structure
PDB8fx2 Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IRP A D145 I146 D148 S149 G150 T152 K177 Y198 V199 D130 I131 D133 S134 G135 T137 K162 Y183 V184
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8fx2, PDBe:8fx2, PDBj:8fx2
PDBsum8fx2
PubMed37418678
UniProtQ4DGA2

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