Structure of PDB 8fx1 Chain A

Receptor sequence
>8fx1A (length=215) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
HVVSRNAEGVIVVDGKAYPMAEELVATESVIQRSIKAVAKQIADFYRPLS
HRDTHGGGGVAPISDENPLIIISVLKGSYIFTADMVRYLGDYGLPHVVDF
LRVASYKMQLLAETQFKALRGKHVLILEDIVDSGKTLRYILDKVQREHQP
ATLKVCVLADKPGGRRVTMQPDFVCLTVPNKYVIGYGFEVNDRFRCFRHI
FTLRPGEARRYPAHL
3D structure
PDB8fx1 Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YC9 A E144 D145 I146 D148 S149 T152 Y198 V199 E128 D129 I130 D132 S133 T136 Y182 V183
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8fx1, PDBe:8fx1, PDBj:8fx1
PDBsum8fx1
PubMed37418678
UniProtQ4DGA2

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