Structure of PDB 8fti Chain A

Receptor sequence

>8ftiA (length=737) Species: 2026780 (Planctomycetota bacterium) [Search protein sequence]

LSIDEYQGARKWCFTIAFNKALVNRDKNDGLFVESLLRHEKYSKHDWYDE
DTRALIKCSTQAANAKAEALANYFSAYRHSPGCLTFTAEDELRTIMERAY
ERAIFECRRRETEVIIEFPSLFEGDRITTAGVVFFVSFFVERRVLDRLYG
AVSGLKKNEGQYKLTRKALSMYCLKDSRFTKAWDKRVLLFRDILAQLGRI
PAEAYEYYHGEQGDDNEGTNPKRHKDKFIEFALHYLEAQHSEICFGRRHI
VRKHRTKGKVVVDFSKKDEDQSYYISKNNVIVRIDKNAGPRSYRMGLNEL
KYLVLLSLQGKGDDAIAKLYRYRQHVENILDVVKVTDKDNHVFLPRFVLE
QHGIGRKAFKQRIDGRVKHVRGVWEKKKAATNEMTLHEKARDILQYVNEN
CTRSFNPGEYNRLLVCLVGKDVENFQAGLKRLQLAERIDGRVYSIFAQTS
TINEMHQVVCDQILNRLCRIGDQKLYDYVGLGKKDEIDYKQKVAWFKEHI
SIRRGFLRKKFWYDSKKGFAKLVEEHLESGGGQRDVGLDKKYYHIDAIGR
FEGANPALYETLARDRLCLMMAQYFLGSVRKELGNKIVWSNDSIELPVEG
SVGNEKSIVFSVSDYGKLYVLDDAEFLGRICEYFMPHEKGKIRYHTVYEK
GFRAYNDLQKKCVEAVLAFEEKVVKAKKDFREILAQTMCKEAEKTAVNKV
ARAFFAHHLKFVIDEFGLFSDVMKKYGIEKEWKFPVK

3D structure

PDB

8fti Structural basis for the activation of a compact CRISPR-Cas13 nuclease

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R155 D159 S190 R191 F192 T193 R204 D205 E235 K243 Y302 K305 R322 F371 P373 R374 F375 R394 W402 L414 H415 S432 P435 Y438 V446 Y506 V507 K511 K512 D513 K520 W523 S529 R531 R532 K537 R578 F579 P584 E588 H673 R681	R142 D146 S177 R178 F179 T180 R191 D192 E217 K225 Y274 K277 R294 F343 P345 R346 F347 R366 W374 L386 H387 S404 P407 Y410 V418 Y478 V479 K483 K484 D485 K492 W495 S501 R503 R504 K509 R550 F551 P556 E560 H645 R653

External links

PDB	RCSB:8fti, PDBe:8fti, PDBj:8fti
PDBsum	8fti
PubMed	37730702
UniProt	A0A660UUL5

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