Structure of PDB 8fs3 Chain A

Receptor sequence

>8fs3A (length=437) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

GEQWYEKFKPNCLEQVAIHKRKLKDVQEALDAMFLPNAKHRILLLSGPSG
CSKSTVIKELSKILVPKYRQNKVTEFRGDCIVNDLPQMESFSEFLKGARY
LVMSNLSLILIEDLPNVFHIDTRRRFQQLILQWLYSSEPLLPPLVICITE
CEIPENDNNYRKFGIDYTFSAETIMNKEILMHPRLKRIKFNPINSTLLKK
HLKFICVQNMKMLKEKNKWNKRQEVIDYIAQETGDIRSAITTLQFWATSS
GSLPISTRESTISYFHAIGKVIHGSHSTNNDNEMINNLFENSNNLLSKED
FKLGILENYNTFNKGEFSISDASSIVDCLSECDNMNGLPESNEYGLREVR
KTFRNISKQGHNHGTVYFPREWKVRKLQNSFKVQAEDWLNVSLYKYNAVH
SFRNITLEFGYYAPLIRKCQSYKKIDVVDRIGGPIEA

3D structure

PDB

8fs3 Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.

Chain

Resolution

2.93 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R83 K84 N191 H194 N234 N266 N269 F340 V441 Y442 F443 W447 K451	R21 K22 N116 H119 N159 N191 N194 F265 V366 Y367 F368 W372 K376
BS02	dna	A	H341 H348 G349 H351 N437 H438	H266 H273 G274 H276 N362 H363
BS03	AGS	A	P72 S111 G112 S114 K115 S116 T117 T224 R312 I315	P10 S49 G50 S52 K53 S54 T55 T149 R237 I240

Gene Ontology

	Molecular Function
GO:0003689	DNA clamp loader activity

	Biological Process
GO:0000077	DNA damage checkpoint signaling
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus
GO:0031389	Rad17 RFC-like complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8fs3, PDBe:8fs3, PDBj:8fs3
PDBsum	8fs3
PubMed	37205533
UniProt	P32641\|RAD24_YEAST Checkpoint protein RAD24 (Gene Name=RAD24)

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