Structure of PDB 8fqh Chain A

Receptor sequence
>8fqhA (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNK
WWYDKGECGA
3D structure
PDB8fqh The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.
ChainA
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y450 P478 L479 T480 L650 S654 T655 E705 Y58 P86 L87 T88 L135 S139 T140 E190
BS02 CYZ A K493 P494 S497 S754 L759 D760 K101 P102 S105 S239 L244 D245
BS03 CYZ A I481 S729 K730 G731 I89 S214 K215 G216
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fqh, PDBe:8fqh, PDBj:8fqh
PDBsum8fqh
PubMed38409505
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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