Structure of PDB 8fpi Chain A

Receptor sequence
>8fpiA (length=1357) Species: 11259 (Human respiratory syncytial virus A2) [Search protein sequence]
NVYLTDSYLKGVISFSECNALGSYIFNGPYLKNDYTNLISRQNPLIEHMN
LKKLNITQSLISKYHKGEIKLEEPTYFQSLLMTYKSMTSSEQIATTNLLK
KIIRRAIEISDVKVYAILNKLGLTIKTTLLKKLMCSMQHPPSWLIHWFNL
YTKLNNILTQYRSNEVKNHGFTLIDNQTLSGFQFILNQYGCIVYHKELKR
ITVTTYNQFLTWKDISLSRLNVCLITWISNCLNTLNKSLGLRCGFNNVIL
TQLFLYGDCILKLFHNEGFYIIKEVEGFIMSLILNITEEDQFRKRFYNSM
LNNITDAANKAQKNLLSRVCHTLLDKTVSDNIINGRWIILLSKFLKLIKL
AGDNNLNNLSELYFLFRIFGHPMVDERQAMDAVKINCNETKFYLLSSLSM
LRGAFIYRIIKGFVNNYNRWPTLRNAIVLPLRWLTYYKLNTYPSLLELTE
RDLIVLSGLRFYREFRLPKKVDLEMIINDKAISPPKNLIWTSFPRNYMPS
HIQNYIEHEKLKFSESDKSRRVLEYYLRDNKFNECDLYNCVVNQSYLNNP
NHVVSLTFAMQPGMFRQVQILAEKMIAENILQFFPESYISKCSIITDLSK
FNQAFRYETSCICSDVLDELHGVQSLFSWLHLTIPHVTIICTYRHAPPYI
GDHIVDLNNVDEQSGLYRYHMGGIEGWCQKLWTIEAISLLDLISLKGKFS
ITALINGDNQSIDISKPIRLMEGQTHAQADYLLALNSLKLLYKEYAGIGH
KLKGTETYISRDMQFMSKTIQHNGVYYPASIKKVLRVGPWINTILDDFKV
SLESIGSLTQELEYRGESLLCSLIFRNVWLYNQIALQLKNHALCNNKLYL
DILKVLKHLKTFFNLDNIDTALTLYMNLPMLFGGGDPNLLYRSFYRRTPD
FLTEAIVHSVFILSYYTNHDLKDKLQDLSDDRLNKFLTCIITFDKNPNAE
FVTLMRDPQALGSERQAKITSEINRLAVTEVLSTAPNKIFSKSAQHYTTT
EIDLNDIMQNIEPTYPHGLRVVYESLPFYKAEKIVNLISGTKSITNILEK
TSAIDLTDIDRATEMMRKNITLLIRILPLDCNRDKREILSMENLSITELS
KYVRERSWSLSNIVGVTSPSIMYTMDIKYTTSTISSGIIIEKYNVNSLTR
GERGPTKPWVGSSTQEKKTMPVYNRQVLTKKQRDQIDLLAKLDWVYASID
NKDEFMEELSIGTLGLTYEKAKKLFPQYLSVNYLHRLTVSSRPCEFPASI
PAYRTTNYHFDTSPINRILTEKYGDEDIDIVFQNCISFGLSLMSVVEQFT
NVCPNRIILIPKLNEIHLMKPPIFTGDVDIHKLKQVIQKQHMFLPDKISL
TQYVELF
3D structure
PDB8fpi Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases.
ChainA
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y6L A G1218 V1219 I1241 H1338 R1345 I1368 N1369 L1372 E1379 I1381 I1383 V1384 F1385 M1422 G1115 V1116 I1138 H1235 R1242 I1265 N1266 L1269 E1276 I1278 I1280 V1281 F1282 M1319
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0006370 7-methylguanosine mRNA capping

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Molecular Function
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Biological Process
External links
PDB RCSB:8fpi, PDBe:8fpi, PDBj:8fpi
PDBsum8fpi
PubMed37337079
UniProtP28887|L_HRSVA RNA-directed RNA polymerase L (Gene Name=L)

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