Structure of PDB 8fpe Chain A

Receptor sequence
>8fpeA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVAAKWSQVRKDLCSL
KVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAK
VISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLE
DTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQH
RVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQ
RLLRIQDIHPFATPLMQELFGITGS
3D structure
PDB8fpe Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y5B A C207 S208 M243 M246 Q285 F288 W299 E321 H407 C48 S49 M84 M87 Q126 F129 W140 E162 H248
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8fpe, PDBe:8fpe, PDBj:8fpe
PDBsum8fpe
PubMed36848571
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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