Structure of PDB 8fp3 Chain A

Receptor sequence
>8fp3A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVE
CTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKS
RRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADF
GMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEML
CGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLG
SLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDF
IKEEPVLTPIDEGHLPMINQDEFRNFEYVSP
3D structure
PDB8fp3 Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y3I A L361 F366 V369 A382 T417 M433 E434 F435 V436 L486 A496 F644 L13 F18 V21 A34 T69 M85 E86 F87 V88 L138 A148 F296
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8fp3, PDBe:8fp3, PDBj:8fp3
PDBsum8fp3
PubMed36940470
UniProtP24723|KPCL_HUMAN Protein kinase C eta type (Gene Name=PRKCH)

[Back to BioLiP]