BioLiP

>8fo9A (length=1173) Species: 9606 (Homo sapiens) [Search protein sequence]

AVPYNRMKLMIVGNTGSGKTTLLQQLMKMQSATVGIDVKDWPIQIRDKRK
RDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWL
FNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDY
HFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIIL
SERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHF
QDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFL
SKKRKFPKNYMTQYFKLIALPIGEEYLLVPSSLSDHRPVIELPHCENSEI
IIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEE
WFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLL
VNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSF
GSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGI
RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI
IYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQG
KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCL
TRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYT
SEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEK
MTDSVTCLYCNSFQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGN
VSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFS
YAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLRE
VTVKSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNS
VRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEV
QNLEKHIEVRKELAEKMRRTSVE

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

GDP

G1346 K1347 T1348 Q1365 A1367 T1368 A1396 G1397 H1453

G18 K19 T20 Q30 A32 T33 A61 G62 H118

BS02

ATP

L1885 V1893 E1948 A1950 S1951 G1953 S1954 R1957 L2001

L545 V553 E608 A610 S611 G613 S614 R617 L661

Molecular Function

GO:0000149

SNARE binding

GO:0000287

magnesium ion binding

GO:0003779

actin binding

GO:0003924

GTPase activity

GO:0004672

protein kinase activity

GO:0004674

protein serine/threonine kinase activity

GO:0004706

JUN kinase kinase kinase activity

GO:0004709

MAP kinase kinase kinase activity

GO:0005096

GTPase activator activity

protein binding

ATP binding

GTP binding

microtubule binding

tubulin binding

kinase activity

hydrolase activity

syntaxin-1 binding

signaling receptor complex adaptor activity

GO:0030276

clathrin binding

GO:0031267

small GTPase binding

GO:0034211

GTP-dependent protein kinase activity

GO:0036479

peroxidase inhibitor activity

GO:0039706

co-receptor binding

GO:0042802

identical protein binding

GO:0042803

protein homodimerization activity

GO:0044024

histone H2AS1 kinase activity

GO:0044325

transmembrane transporter binding

GO:0051018

protein kinase A binding

GO:0106310

protein serine kinase activity

GO:1904713

beta-catenin destruction complex binding

	Biological Process
GO:0000165	MAPK cascade
GO:0001934	positive regulation of protein phosphorylation
GO:0006338	chromatin remodeling
GO:0006468	protein phosphorylation
GO:0006606	protein import into nucleus
GO:0006897	endocytosis
GO:0006914	autophagy
GO:0006979	response to oxidative stress
GO:0007005	mitochondrion organization
GO:0007029	endoplasmic reticulum organization
GO:0007030	Golgi organization
GO:0007040	lysosome organization
GO:0007154	cell communication
GO:0007165	signal transduction
GO:0007254	JNK cascade
GO:0007266	Rho protein signal transduction
GO:0007283	spermatogenesis
GO:0007528	neuromuscular junction development
GO:0008104	protein localization
GO:0008340	determination of adult lifespan
GO:0009267	cellular response to starvation
GO:0009966	regulation of signal transduction
GO:0010468	regulation of gene expression
GO:0010506	regulation of autophagy
GO:0010508	positive regulation of autophagy
GO:0010955	negative regulation of protein processing
GO:0010977	negative regulation of neuron projection development
GO:0014041	regulation of neuron maturation
GO:0016242	negative regulation of macroautophagy
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0019722	calcium-mediated signaling
GO:0021756	striatum development
GO:0021772	olfactory bulb development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0031398	positive regulation of protein ubiquitination
GO:0031647	regulation of protein stability
GO:0032091	negative regulation of protein binding
GO:0032092	positive regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034260	negative regulation of GTPase activity
GO:0034599	cellular response to oxidative stress
GO:0034614	cellular response to reactive oxygen species
GO:0035556	intracellular signal transduction
GO:0035564	regulation of kidney size
GO:0035640	exploration behavior
GO:0035641	locomotory exploration behavior
GO:0035751	regulation of lysosomal lumen pH
GO:0040012	regulation of locomotion
GO:0042391	regulation of membrane potential
GO:0043068	positive regulation of programmed cell death
GO:0043406	positive regulation of MAP kinase activity
GO:0045746	negative regulation of Notch signaling pathway
GO:0045860	positive regulation of protein kinase activity
GO:0046039	GTP metabolic process
GO:0046777	protein autophosphorylation
GO:0048312	intracellular distribution of mitochondria
GO:0048812	neuron projection morphogenesis
GO:0051646	mitochondrion localization
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0051900	regulation of mitochondrial depolarization
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060070	canonical Wnt signaling pathway
GO:0060079	excitatory postsynaptic potential
GO:0060159	regulation of dopamine receptor signaling pathway
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0060628	regulation of ER to Golgi vesicle-mediated transport
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0061001	regulation of dendritic spine morphogenesis
GO:0070585	protein localization to mitochondrion
GO:0070973	protein localization to endoplasmic reticulum exit site
GO:0071287	cellular response to manganese ion
GO:0071407	cellular response to organic cyclic compound
GO:0090140	regulation of mitochondrial fission
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0090394	negative regulation of excitatory postsynaptic potential
GO:0140058	neuron projection arborization
GO:0141161	regulation of cAMP/PKA signal transduction
GO:1900242	regulation of synaptic vesicle endocytosis
GO:1900244	positive regulation of synaptic vesicle endocytosis
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902499	positive regulation of protein autoubiquitination
GO:1902692	regulation of neuroblast proliferation
GO:1902803	regulation of synaptic vesicle transport
GO:1902823	negative regulation of late endosome to lysosome transport
GO:1902902	negative regulation of autophagosome assembly
GO:1903125	negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903215	negative regulation of protein targeting to mitochondrion
GO:1903217	negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903351	cellular response to dopamine
GO:1903980	positive regulation of microglial cell activation
GO:1904887	Wnt signalosome assembly
GO:1905279	regulation of retrograde transport, endosome to Golgi
GO:1905289	regulation of CAMKK-AMPK signaling cascade
GO:2000172	regulation of branching morphogenesis of a nerve
GO:2000300	regulation of synaptic vesicle exocytosis
GO:2000377	regulation of reactive oxygen species metabolic process

Biological Process

GO:0000165

MAPK cascade

GO:0001934

positive regulation of protein phosphorylation

GO:0006338

chromatin remodeling

GO:0006468

protein phosphorylation

GO:0006606

protein import into nucleus

GO:0006897

endocytosis

GO:0006914

autophagy

GO:0006979

response to oxidative stress

GO:0007005

mitochondrion organization

GO:0007029

endoplasmic reticulum organization

GO:0007030

Golgi organization

GO:0007040

lysosome organization

cell communication

signal transduction

JNK cascade

Rho protein signal transduction

GO:0007283

spermatogenesis

GO:0007528

neuromuscular junction development

GO:0008104

protein localization

GO:0008340

determination of adult lifespan

GO:0009267

cellular response to starvation

GO:0009966

regulation of signal transduction

GO:0010468

regulation of gene expression

GO:0010506

regulation of autophagy

GO:0010508

positive regulation of autophagy

GO:0010955

negative regulation of protein processing

GO:0010977

negative regulation of neuron projection development

GO:0014041

regulation of neuron maturation

GO:0016242

negative regulation of macroautophagy

GO:0016310

phosphorylation

GO:0018105

peptidyl-serine phosphorylation

GO:0018107

peptidyl-threonine phosphorylation

GO:0019722

calcium-mediated signaling

GO:0021756

striatum development

GO:0021772

olfactory bulb development

GO:0022028

tangential migration from the subventricular zone to the olfactory bulb

GO:0030154

cell differentiation

GO:0030182

neuron differentiation

GO:0031398

positive regulation of protein ubiquitination

GO:0031647

regulation of protein stability

GO:0032091

negative regulation of protein binding

GO:0032092

positive regulation of protein binding

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

GO:0032760

positive regulation of tumor necrosis factor production

GO:0034260

negative regulation of GTPase activity

GO:0034599

cellular response to oxidative stress

GO:0034614

cellular response to reactive oxygen species

GO:0035556

intracellular signal transduction

GO:0035564

regulation of kidney size

GO:0035640

exploration behavior

GO:0035641

locomotory exploration behavior

GO:0035751

regulation of lysosomal lumen pH

GO:0040012

regulation of locomotion

GO:0042391

regulation of membrane potential

GO:0043068

positive regulation of programmed cell death

GO:0043406

positive regulation of MAP kinase activity

GO:0045746

negative regulation of Notch signaling pathway

GO:0045860

positive regulation of protein kinase activity

GO:0046039

GTP metabolic process

GO:0046777

protein autophosphorylation

GO:0048312

intracellular distribution of mitochondria

GO:0048812

neuron projection morphogenesis

GO:0051646

mitochondrion localization

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

GO:0051900

regulation of mitochondrial depolarization

GO:0051966

regulation of synaptic transmission, glutamatergic

GO:0060070

canonical Wnt signaling pathway

GO:0060079

excitatory postsynaptic potential

GO:0060159

regulation of dopamine receptor signaling pathway

GO:0060161

positive regulation of dopamine receptor signaling pathway

GO:0060628

regulation of ER to Golgi vesicle-mediated transport

GO:0060828

regulation of canonical Wnt signaling pathway

GO:0061001

regulation of dendritic spine morphogenesis

GO:0070585

protein localization to mitochondrion

GO:0070973

protein localization to endoplasmic reticulum exit site

GO:0071287

cellular response to manganese ion

GO:0071407

cellular response to organic cyclic compound

GO:0090140

regulation of mitochondrial fission

GO:0090263

positive regulation of canonical Wnt signaling pathway

GO:0090394

negative regulation of excitatory postsynaptic potential

GO:0140058

neuron projection arborization

GO:0141161

regulation of cAMP/PKA signal transduction

GO:1900242

regulation of synaptic vesicle endocytosis

GO:1900244

positive regulation of synaptic vesicle endocytosis

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO:1902499

positive regulation of protein autoubiquitination

GO:1902692

regulation of neuroblast proliferation

GO:1902803

regulation of synaptic vesicle transport

GO:1902823

negative regulation of late endosome to lysosome transport

GO:1902902

negative regulation of autophagosome assembly

GO:1903125

negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation

GO:1903215

negative regulation of protein targeting to mitochondrion

GO:1903217

negative regulation of protein processing involved in protein targeting to mitochondrion

GO:1903351

cellular response to dopamine

GO:1903980

positive regulation of microglial cell activation

GO:1904887

Wnt signalosome assembly

GO:1905279

regulation of retrograde transport, endosome to Golgi

GO:1905289

regulation of CAMKK-AMPK signaling cascade

GO:2000172

regulation of branching morphogenesis of a nerve

GO:2000300

regulation of synaptic vesicle exocytosis

GO:2000377

regulation of reactive oxygen species metabolic process

	Cellular Component
GO:0000139	Golgi membrane
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005798	Golgi-associated vesicle
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0008021	synaptic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031966	mitochondrial membrane
GO:0032473	cytoplasmic side of mitochondrial outer membrane
GO:0032839	dendrite cytoplasm
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0044753	amphisome
GO:0044754	autolysosome
GO:0045121	membrane raft
GO:0045202	synapse
GO:0045335	phagocytic vesicle
GO:0070062	extracellular exosome
GO:0070971	endoplasmic reticulum exit site
GO:0097487	multivesicular body, internal vesicle
GO:0098794	postsynapse
GO:0098978	glutamatergic synapse
GO:0099400	caveola neck
GO:0099523	presynaptic cytosol
GO:1990904	ribonucleoprotein complex
GO:1990909	Wnt signalosome

Cellular Component

Golgi membrane

extracellular space

cytoplasm

mitochondrion

mitochondrial outer membrane

GO:0005743

mitochondrial inner membrane

mitochondrial matrix

lysosome

endosome

endoplasmic reticulum

GO:0005789

endoplasmic reticulum membrane

GO:0005794

Golgi apparatus

GO:0005798

Golgi-associated vesicle

trans-Golgi network

cytosol

cytoskeleton

plasma membrane

microvillus

synaptic vesicle

axon

dendrite

growth cone

synaptic vesicle membrane

GO:0031410

cytoplasmic vesicle

GO:0031966

mitochondrial membrane

GO:0032473

cytoplasmic side of mitochondrial outer membrane

dendrite cytoplasm

cell projection

neuron projection

neuronal cell body

terminal bouton

perikaryon

intracellular membrane-bounded organelle

amphisome

autolysosome

membrane raft

synapse

phagocytic vesicle

extracellular exosome

GO:0070971

endoplasmic reticulum exit site

GO:0097487

multivesicular body, internal vesicle

GO:0098794

postsynapse

GO:0098978

glutamatergic synapse

GO:0099400

caveola neck

GO:0099523

presynaptic cytosol

GO:1990904

ribonucleoprotein complex

GO:1990909

Wnt signalosome

PDB	RCSB:8fo9, PDBe:8fo9, PDBj:8fo9
PDBsum	8fo9
PubMed	38127736
UniProt	Q5S007\|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

Structure of PDB 8fo9 Chain A