Structure of PDB 8fny Chain A

Receptor sequence
>8fnyA (length=497) Species: 9606 (Homo sapiens) [Search protein sequence]
NSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLD
DEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPV
DRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLF
HLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQ
GVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPF
DLSPRERDAVNQNTKLLQSAKTILRGTEEKCHLPRASAVALEVQRLNALD
LEKIGKSILGKVHLAMVRYHEGGRFCEKEEWDQESAVFHLEHAANLGELE
AIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMIL
VARAFDSGQNLSPDRCQDWLEALHWYNTALEMTEPRYMMLAREAEMLFTG
GYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
3D structure
PDB8fny ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.20: [elongation factor 2] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A A142 R144 C146 K170 E229 Y231 I232 Y236 D284 A66 R68 C70 K94 E153 Y155 I156 Y160 D208
BS02 ADP A R114 R116 K151 S153 N154 F155 Y167 Q211 H230 R38 R40 K75 S77 N78 F79 Y91 Q135 H154
BS03 ZN A H260 H312 C314 C318 H184 H236 C238 C242
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0004686 elongation factor-2 kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8fny, PDBe:8fny, PDBj:8fny
PDBsum8fny
PubMed37068230
UniProtO00418|EF2K_HUMAN Eukaryotic elongation factor 2 kinase (Gene Name=EEF2K)

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