Structure of PDB 8fn3 Chain A

Receptor sequence

>8fn3A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

8fn3 Crystal structure of human DNA polymerase eta incorporating dITP across dC

Chain

Resolution

2.17 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 R61 S62 W64 K86 P316 K317 T318 G320 S322 K323 N324 P326 R351	Q37 Y38 W41 R60 S61 W63 K85 P310 K311 T312 G314 S316 K317 N318 P320 R345
BS02	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 R377 L381 R382 C384	S112 E115 K218 S251 G253 G254 K255 L256 R371 L375 R376 C378
BS03	Y43	A	D15 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D14 C15 F16 F17 I47 Y51 R54 R60 D114 K225
BS04	CA	A	D13 M14 D115	D12 M13 D114
BS05	CA	A	D13 D115 E116	D12 D114 E115

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8fn3, PDBe:8fn3, PDBj:8fn3
PDBsum	8fn3
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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