Structure of PDB 8fm5 Chain A

Receptor sequence
>8fm5A (length=335) Species: 587638 (HIV-1 06TG.HT008) [Search protein sequence]
KTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLANVTENFNMWKN
DMVEQMHEDIISLWDESLKPCVKLTGGSAITQACPKVSFDPIPLHYCAPA
GFAILKCNNKTFNGTGPCRNVSTVQCTHGIKPVVSTQLLLNGSLAEEEII
IRSENLTNNAKTIIVHLNESVNIVCTRPNNIRQAHCNINESKWNNTLQKV
GEELAKHFPSKTIKFEPSSGGDLEITTHSFNCRGEFFYCNTSDLFNGTYR
NGTYNHTGRSSNGTITLQCKIKQIINMWQEVGRAIYAPPIEGEITCNSNI
TGLLLLRDDTETFRPGGGDMRDNWRSELYKYKVVE
3D structure
PDB8fm5 Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y2E A V255 S256 E370 S375 F376 F382 I424 N425 M426 W427 Q428 E429 V430 G431 G472 G473 D474 M475 V134 S135 E224 S229 F230 F236 I275 N276 M277 W278 Q279 E280 V281 G282 G317 G318 D319 M320
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8fm5, PDBe:8fm5, PDBj:8fm5
PDBsum8fm5
PubMed36961924
UniProtC6G099

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