Structure of PDB 8fkg Chain A

Receptor sequence
>8fkgA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
GQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLND
QVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDF
MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL
LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDM
SLHPLLQEIYKDLY
3D structure
PDB8fkg Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33486
ChainA
Resolution2.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T297 K301 V315 L318 K319 H323 T84 K88 V102 L105 K106 H110
BS02 Y62 A I281 F282 C285 Q286 H323 F363 H449 Y473 L476 Y477 I68 F69 C72 Q73 H110 F150 H236 Y260 L263 Y264
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkg, PDBe:8fkg, PDBj:8fkg
PDBsum8fkg
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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