Structure of PDB 8fkf Chain A

Receptor sequence
>8fkfA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
GQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEDKIEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQ
VTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFM
EPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL
QALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMS
LHPLLQEIYKDLY
3D structure
PDB8fkf Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR36706
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V293 T297 K301 V315 L318 K319 H323 V79 T83 K87 V101 L104 K105 H109
BS02 Y5X A F282 C285 Q286 H323 F363 M364 H449 Y473 L476 Y477 F68 C71 Q72 H109 F149 M150 H235 Y259 L262 Y263
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkf, PDBe:8fkf, PDBj:8fkf
PDBsum8fkf
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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