Structure of PDB 8fkc Chain A

Receptor sequence
>8fkcA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
GQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDLY
3D structure
PDB8fkc Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and SR33544
ChainA
Resolution1.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V293 T297 K301 L318 K319 H323 V76 T80 K84 L101 K102 H106
BS02 Y5F A F282 C285 Q286 H323 F363 M364 K367 V446 H449 Y473 L476 Y477 F65 C68 Q69 H106 F146 M147 K150 V229 H232 Y256 L259 Y260
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fkc, PDBe:8fkc, PDBj:8fkc
PDBsum8fkc
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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