Structure of PDB 8fk4 Chain A

Receptor sequence
>8fk4A (length=827) Species: 1309 (Streptococcus mutans) [Search protein sequence]
KYNQVYDRSAQSFEHVDHYLTAESWYRPKYILKDGKTWTQSTEKDFRPLL
MTWWPSQETQRQYVNYMNAQLGINKTYDDTSNQLQLNIAAATIQAKIEAK
ITTLKNTDWLRQTISAFVKTQSAWNSDSEKPFDDHLQNGAVLYDNEGKLT
PYANSNYRILNRTPTNQTGKKDPRYTADNTIGGYEFLLANDVDNSNPVVQ
AEQLNWLHFLMNFGNIYANDPDANFDSIRVDAVDNVDADLLQIAGDYLKA
AKGIHKNDKAANDHLSILEAWSDNDTPYLHDDGDNMINMDNKLRLSLLFS
LAKPLNQRSGMNPLITNSLVNRTDDNAETAAVPSYSFIRAHDSEVQDLIR
DIIKAEINPNVVGYSFTMEEIKKAFEIYNKDLLATEKKYTHYNTALSYAL
LLTNKSSVPRVYYGDMFTDDGQYMAHKTINYEAIETLLKARIKYVSGGQA
MRNQQVGNSEIITSVRYGKGALKATDTGDRTTRTSGVAVIEGNNPSLRLK
ASDRVVVNMGAAHKNQAYRPLLLTTDNGIKAYHSDQEAAGLVRYTNDRGE
LIFTAADIKGYANPQVSGYLGVWVPVGAAADQDVRVAASTAPSTDGKSVH
QNAALDSRVMFEGFSNFQAFATKKEEYTNVVIAKNVDKFAEWGVTDFEMA
PQYVSSTDGSFLDSVIQNGYAFTDRYDLGISKPNKYGTADDLVKAIKALH
SKGIKVMADWVPDQMYAFPEKEVVTATRVDKFGKPVEGSQIKSVLYVADS
KSSGKDQQAKYGGAFLEELQAKYPELFARKQISTGVPMDPSVKIKQWSAK
YFNGTNILGRGAGYVLKDQATNTYFNI
3D structure
PDB8fk4 The catalytic domains of Streptococcus mutans glucosyltransferases: a structural analysis
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.5: dextransucrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A W491 N511 R514 W271 N291 R294
BS02 AC1 A D451 A452 N455 E489 H561 D562 D883 Y890 Q934 D231 A232 N235 E269 H341 D342 D663 Y670 Q714
BS03 CA A E405 D411 N455 D933 E185 D191 N235 D713
Gene Ontology
Molecular Function
GO:0046527 glucosyltransferase activity
Biological Process
GO:0009250 glucan biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8fk4, PDBe:8fk4, PDBj:8fk4
PDBsum8fk4
PubMed37158310
UniProtP08987|GTFB_STRMU Glucosyltransferase-I (Gene Name=gtfB)

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