Structure of PDB 8fjn Chain A

Receptor sequence
>8fjnA (length=235) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
GELGAGTPHEPYNLPLRGNPNKSGCHHCLADQCHCVFFERLLDATFRRLK
SLLPTFVSRMVRLMEITSEDTFYDLGCGNGSILFQVAFLTGARCVGIEIS
EHNAKVAKKAWEVIRPELEGSSGRSMSEVNIITSDMTKILADERLFESER
GKTVILLSNLLFPKSLTHYLSERFRRVPSGTRILCFDDLYPHSRSVAAIR
DPEAFRLFAMTDYRWQECSVEWCTRDGPFFIHRRR
3D structure
PDB8fjn Structure and Mechanism of the atypical Trypanosoma brucei DOT1A histone H3K76 methyltransferase
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.360: [histone H3]-lysine(79) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A K110 S111 L112 D134 G136 I142 E158 I159 D195 M196 K50 S51 L52 D74 G76 I82 E98 I99 D135 M136
BS02 ZN A C69 C72 C77 C79 C25 C28 C33 C35
BS03 CA A E207 R236 E147 R176
Gene Ontology
Molecular Function
GO:0031151 histone H3K79 methyltransferase activity
Biological Process
GO:0051726 regulation of cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:8fjn, PDBe:8fjn, PDBj:8fjn
PDBsum8fjn
PubMed38503750
UniProtQ581Z0

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