Structure of PDB 8fgw Chain A

Receptor sequence
>8fgwA (length=1081) Species: 9606 (Homo sapiens) [Search protein sequence]
MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLESNLSMN
QTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRN
KSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTW
SADSKVLLFGMANGEIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYH
GTEGYVEPDCPCLAVCFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHM
GSVLAVAGFQKAVNIVQFYTPFGEHLGTLKVPGKEISALSWEGGGLKIAL
AVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYV
KYVKGLISITTCGDFCILATKADATFVLVLCNSIGTPLDPKYIDIVPLFV
AMTKTHVIAASKEAFYTWQYRVASRKEGRERIYHVDDTPSGSMGVLDYSK
TIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQ
LSLNCNSSRLAIIDISGVLTFFDLDARVTVVGELLKLERRDVWDMKWAKD
NPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKD
PEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAE
AALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRF
EEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANN
AIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE
NHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVEL
AKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIA
DEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKFTDNAWRGAEAYHFFILA
QRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRAFGTCSK
AFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNKLPTCVATGSPITEY
QFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
3D structure
PDB8fgw Human IFT-A complex structures provide molecular insights into ciliary transport.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1155 C1158 C1173 C1055 C1058 C1073
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0030030 cell projection organization
GO:0035721 intraciliary retrograde transport
GO:0042073 intraciliary transport
GO:0060271 cilium assembly
GO:0061512 protein localization to cilium
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0036064 ciliary basal body
GO:0097542 ciliary tip

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fgw, PDBe:8fgw, PDBj:8fgw
PDBsum8fgw
PubMed36775821
UniProtQ9P2L0|WDR35_HUMAN WD repeat-containing protein 35 (Gene Name=WDR35)

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