Structure of PDB 8fgm Chain A

Receptor sequence
>8fgmA (length=415) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPRPEDVATKD
QLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELI
YGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNK
GNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFT
EICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFE
WFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNS
RYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHH
SATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTP
SFEYQPDPWNTHVWK
3D structure
PDB8fgm Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A W414 R419 C420 F589 W592 E597 W683 F709 Y711 W107 R112 C113 F282 W285 E290 W376 F402 Y404
BS02 H4B A S339 R601 V682 W683 S37 R294 V375 W376
BS03 XVA A Q483 R486 V572 F589 S590 G591 E597 Q176 R179 V265 F282 S283 G284 E290
BS04 H4B A F696 H697 Q698 E699 F389 H390 Q391 E392
BS05 ZN A C331 C336 C29 C34
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8fgm, PDBe:8fgm, PDBj:8fgm
PDBsum8fgm
PubMed37433128
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

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