Structure of PDB 8ffs Chain A

Receptor sequence
>8ffsA (length=1033) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYP
GADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDP
DIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMN
QDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTP
VDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNIL
LKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANAL
DTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIIL
VFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVL
AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLS
AVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPI
QKGSHGATTGFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVG
MAWLFVRLPSSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTK
EKDNVESVFAVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARA
MGYFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQ
LFGMVAQHPDVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLG
AAWGGSYVNDFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPF
SAFSTSRWEYGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKL
PSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSV
MLVVPLGVVGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKD
LMEKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQN
AVGTGVMGGMVTATILAIFFVPVFFVVVRRRFS
3D structure
PDB8ffs Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump.
ChainA
Resolution2.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ERY A F136 Q176 F178 F614 F627 V671 F136 Q176 F178 F614 F627 V671
Gene Ontology
Molecular Function
GO:0015562 efflux transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ffs, PDBe:8ffs, PDBj:8ffs
PDBsum8ffs
PubMed37067435
UniProtW9B4M6

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